Associazione del fattore di necrosi tumorale-alfa (TNF-α) con l'obesità
Abstract
Questo lavoro mirava a valutare l'associazione tra il fattore di necrosi tumorale-alfa (TNF-α) e l'obesità, consentendo di definire più chiaramente il ruolo degli adipociti nella salute e nell'obesità e come il TNF-α agisce segnalando le molecole in questo processo, attraverso una letteratura revisione. I dati sono stati raccolti da siti internet e riviste scientifiche, coprendo articoli scientifici a partire dal 1995. Diversi studi sottolineano che l'obesità è caratterizzata da un aumento del tessuto adiposo, oggi considerato un organo endocrino attivo, che secerne una varietà di sostanze metaboliche come ormoni, proteine della coagulazione e diversi fattori pro-infiammatori, incluso il TNF-α. Questo lavoro mira a mostrare l'importanza del TNF-α come citochina multifunzionale con un ruolo di difesa centrale che esercita diverse attività biologiche, nonché lo sviluppo e l'espressione fenotipica dell'obesità, in quanto agisce direttamente sugli adipociti, regolando l'accumulo di grasso e interferendo direttamente con il metabolismo lipidico, inibendo la lipogenesi e aumentando la lipolisi negli adipociti.
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