Type 3 diabetes and physical exercise: intercourses on obesity, insulin resistance and cognitive disorders

  • Letí­cia Andrade Cerrone Grupo de Estudos da Obesidade, Laboratório Interdisciplinar de Doenças Metabólicas, Universidade Federal de São Paulo, Santos-SP, Brasil.
  • Cauê Vazquez La Scala Teixeira Grupo de Estudos da Obesidade, Laboratório Interdisciplinar de Doenças Metabólicas, Universidade Federal de São Paulo, Santos-SP, Brasil. Faculdade de Educação Fí­sica, Faculdade Praia Grande, Praia Grande-SP, Brasil.
  • Renata Astride Rebelo Grupo de Estudos da Obesidade, Laboratório Interdisciplinar de Doenças Metabólicas, Universidade Federal de São Paulo, Santos-SP, Brasil.
  • Danielle Arisa Caranti Grupo de Estudos da Obesidade, Laboratório Interdisciplinar de Doenças Metabólicas, Universidade Federal de São Paulo, Santos-SP, Brasil. Departamento de Biociências, Universidade Federal de São Paulo, Santos-SP, Brasil.
  • Ricardo José Gomes Grupo de Estudos da Obesidade, Laboratório Interdisciplinar de Doenças Metabólicas, Universidade Federal de São Paulo, Santos-SP, Brasil. Departamento de Biociências, Universidade Federal de São Paulo, Santos-SP, Brasil.
Keywords: Alzheimer disease, Cognition, Obesity, Diabetes mellitus, Exercise

Abstract

Introduction and objective: Type 3 Diabetes Mellitus (DM3) is a term recently proposed to refer to the relationship between obesity, insulin resistance, type 2 diabetes mellitus and cognitive disorders. The study presents evidences about the DM3 and shows the role of physical exercise as a non-pharmacological treatment for DM3. Materials and Methods: It was performed a review of papers published between 2000 and 2016 from MEDLINE and LILACS databases. All stages of the review process have been conducted in two independent researchers. Results and discussion: It was observed the relationship between neurological and cognitive disorders with cardiometabolic alterations, insulin resistance and obesity related inflammatory process. Physical exercise (PE) showed beneficial effects on several risk factors for DM3. The term DM3 emphasizes the influence of conditions such as obesity, insulin resistance and type 2 diabetes mellitus on the Alzheimer's disease development. Conclusion: The PE has shown to be an important prevention/treatment strategy. Further studies are needed in PE modalities to consolidate the knowledge in the development of guidelines for PE prescription in the context of DM3.

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Published
2018-06-25
How to Cite
Cerrone, L. A., La Scala Teixeira, C. V., Rebelo, R. A., Caranti, D. A., & Gomes, R. J. (2018). Type 3 diabetes and physical exercise: intercourses on obesity, insulin resistance and cognitive disorders. Brazilian Journal of Obesity, Nutrition and Weight Loss, 12(71), 336-345. Retrieved from https://www.rbone.com.br/index.php/rbone/article/view/706
Issue
Vol. 12 No. 71 (2018)
Section
Scientific Articles - Original

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