Resveratrol: chemical composition and its benefits to health
Abstract
Introduction: Resveratrol (trans-3,5,4'-trihydroxystilbene), a phenolic compound found in grapes and derivatives, has been shown to decrease lipid levels in serum and platelet aggregation, increase HDL cholesterol, decrease LDL-c, and prevent artery blockage. Aim: This literature review aims to present data on resveratrol, its chemical composition and its health benefits, as well as its dietary sources and its nutritional recommendation as a form of prevention for several diseases. Materials and methods: It was carried out through searches in the PubMed, Scielo and Capes Periodical Portals using the descriptors: resveratrol, chemical composition, functional food, totalizing: 42 articles, 30 English studies, 11 studies in Portuguese language and 1 in the polish language. Results and discussion: The results of the studies show resveratrol as a phenolic compound with functional performances as antioxidant, anti-inflammatory and anti-fatigue agents. This has been applied in several diseases playing a positive role in the prevention and treatment of metabolic and degenerative disorders. Conclusion: The most commonly used dose is 15 to 20 mg per day in the form of a capsule, 250 ml of juice or red wine, or the consumption of purple grapes, blueberries, cacao, among others, producing significant health benefits.
References
-Banaszewska, B.; Wrotyńska-Barczyńska, J.; Spaczynski, R.Z.; Pawelczyk, L.; Duleba, A. J. Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial. The Journal of Clinical Endocrinology & Metabolism. Vol. 101. Num. p. 4322-4328. 2016.
-Brasil.Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Portaria nº 398, de 30 de abril de 1999c. Estabelece as diretrizes básicas para análise e comprovação de propriedades funcionais e ou de saúde alegadas em rotulagem de alimentos. 1999.
-Cardozo, M.G.; Medeiros, N.; dos Santos Lacerda, D.; de Almeida, D.C.; Henriques, J.A.P.; Dani, C.; Funchal, C. Effect of chronic treatment with conventional and organic purple grape juices (Vitis labrusca) on rats fed with high-fat diet. Cellular and molecular neurobiology. Vol. 33. Num. 8. p. 1123-1133. 2013.
-Chang, G.R.; Chen, P.L.; Hou, P.H.; Mao, F.C. Resveratrol protects against diet-induced atherosclerosis by reducing low-density lipoprotein cholesterol and inhibiting inflammation in apolipoprotein E-deficient mice. Iranian journal of basic medical sciences. Vol. 18. Num. 11. p. 1063. 2015.
-Chiu, H.F.; Shen, Y.C.; Huang, T.Y.; Venkatakrishnan, K.; Wang, C.K. Cardioprotective efficacy of red wine extract of onion in healthy hypercholesterolemic subjects. Phytotherapy Research. Vol. 30. Num. 3. p. 380-385. 2016.
-De Souza, A.A.; De França, A.C.L.; Bastos, V.M.L.; Toscano, L.T.; Silva, A.S. Efeito da Ingestão de Dose Única de Vinho Tinto na Hipotensão Pós-Exercício. Revista Brasileira de Ciências da Saúde. Vol. 18. p. 3-10. 2014.
-Dohadwala, M.M.; Vita, J.A. Grapes and cardiovascular disease. The Journal of nutrition. Vol. 139. Num. 9. p. 1788S-1793S. 2009.
-Dos Santos Lima, M.; Silani, I.D.S.V.; Toaldo, I.M.; Corrêa, L.C.; Biasoto, A.C.T.; Pereira, G.E.; Bordignon-Luiz, M.T.; Ninow, J.L. Phenolic compounds, organic acids and antioxidant activity of grape juices produced from new Brazilian varieties planted in the Northeast Region of Brazil. Food chemistry. Vol. 161. p. 94-103. 2014.
-Efraim, P.; Alves, A.B.; Jardim, D.C.P. Revisão: Polifenóis em cacau e derivados: teores, fatores de variação e efeitos na saúde. Brazilian Journal of Food Technology. 2011.
-Faghihzadeh, F.; Adibi, P.; Hekmatdoost, A. The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study. British Journal of Nutrition. Vol. 114. Num. 5. p. 796-803. 2015.
-Ferreira, I.C.F.R.; Abreu, R. Stress oxidativo, antioxidantes e fitoquímicos. Bioanálise. p. 32-39. 2007.
-Frankel, E.N.; Waterhouse, A.L.; Kinsella, J.E. Inhibition of human LDL oxidation by resveratrol. The Lancet. Vol. 341. Num. 8852. p. 1103-1104. 1993.
-Freitas, A.A.; Detoni, A.M.; Clemente, E.; Oliveira, C.C. Determinação de resveratrol e características químicas em sucos de uvas produzidas em sistemas orgânico e convencional. Revista Ceres. Vol. 57. Num. 1. p. 1-5. 2010.
-Gallice, W.C.; Messerschmidt, I.; Peralta-Zamora, P. Caracterização espectroscópica multivariada do potencial antioxidante de vinhos. Quim. Nova. Vol. 34. Num. 3. p. 397-403. 2011.
-Gu, J.; Hu, W.; Zhang, D. Resveratrol, a polyphenol phytoalexin, protects against doxorubicin‐induced cardiotoxicity. Journal of cellular and molecular medicine. Vol. 19. Num. 10. p. 2324-2328. 2015.
-Hasler, C.M.; Bloch, A.S.; Thomson, C.A.; Enrione, E.; Manning, C. Position of the American Dietetic Association: functional foods. Journal of the American Dietetic Association. Vol. 104. Num. 5. p. 814-826. 2004.
-Kan, N.W.; Ho, C.S.; Chiu, Y.S.; Huang, W.C.; Chen, P.Y.; Tung, Y.T.; Huang, C.C.Effects of resveratrol supplementation and exercise training on exercise performance in middle-aged mice. Molecules. Vol. 21. Num. 5. p. 661. 2016.
-Lançon, A.; Frazzi, R.; Latruffe, N. Anti-oxidant, anti-inflammatory and anti-angiogenic properties of resveratrol in ocular diseases. Molecules. Vol. 21. Num. 3. p. 304. 2016.
-Langcake, P.; Pryce, R.J. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiological Plant Pathology. Vol. 9. Num. 1. p. 77-86. 1976.
-Lazzarotto, I.P.; Guedes, F.F. Avaliação do conteúdo de trans-resveratrol em vinhos elaborados a partir das variedades de uva bordô e isabel. Revista de Iniciação Científica da ULBRA. Vol. 1. Num. 13. 2015.
-Li, X.; Dai, Y.; Yan, S.; Shi, Y.; Li, J.; Liu, J.; Cha, L.; Mu, J. Resveratrol lowers blood pressure in spontaneously hypertensive rats via calcium-dependent endothelial NO production. Clinical and Experimental Hypertension. Vol. 38. Num. 3. p. 287-293. 2016.
-Liu, H.; Zhang, S.; Zhao, L.; Zhang, Y.; Li, Q.; Chai, X.; Zhang, Y. Resveratrol enhances cardiomyocyte differentiation of human induced pluripotent stem cells through inhibiting canonical WNT signal pathway and enhancing serum response factor-miR-1 axis. Stem cells international. 2016.
-Liu, M.L.; Zhang, S.J. Effects of resveratrol on the protein expression of survivin and cell apoptosis in human gastric cancer cells. J BUON. Vol. 19. p. 713-717. 2014.
-Lutz, M.; Jorquera, K.; Cancino, B.; Ruby, R.; Henriquez, C. Phenolics and antioxidant capacity of table grape (Vitis vinifera L.) cultivars grown in Chile. Journal of food Science. Vol. 76. Num. 7. p. C1088-C1093. 2011.
-Matos, R.S.; Baroncini, L.A.V.; Précoma, L. B.; Winter, G.; Lambach, P.H.; Kaiber, F.; Précoma, D.B. Resveratrol causes antiatherogenic effects in an animal model of atherosclerosis. Arquivos brasileiros de cardiologia. Vol. 98. Num. 2. p. 136-142. 2012.
-Mulero, J.; Abellán, J.; Zafrilla, P.; Amores, D.; Hernández Sánchez, P. Bioactive substances with preventive effect in cardiovascular diseases. Nutr Hosp. Vol. 32. Num. 4. p. 1462-1467. 2015.
-Nonomura, S.; Kanagawa, H.; Makimoto, A. Chemical constituents of polygonaceous plants. i. studies on the components of ko-j o-kon.(polygonum cuspidatum sieb. et zucc.). Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan. Vol. 83. p. 988-990. 1963.
-Peredo-Escárcega, A.E.; Guarner-Lans, V.; Pérez-Torres, I.; Ortega-Ocampo, S.; Carreón-Torres, E.; Castrejón-Tellez, V.; Diaz-Diaz, E.; Rubio-Ruiz, M. E. The combination of resveratrol and quercetin attenuates metabolic syndrome in rats by modifying the serum fatty acid composition and by upregulating SIRT 1 and SIRT 2 expression in white adipose tissue. Evidence-BasedComplementary and Alternative Medicine. 2015.
-Pereira Júnior, E.S.; Medeiros, N.S.; Dani, C.; Funchal, C. Suco de uva: fonte de compostos bioativos com benefício à saúde. Nutrição Brasil. Vol. 12. Num. 3. 2013.
-Pieszka, M.; Szczurek, P.; Ropka-Molik, K., Oczkowicz, M.; Pieszka, M. Rola resweratrolu w regulacji metabolizmu komórkowego. Postepy Hig Med Dosw (online). Vol. 70. p. 1117-1123. 2016.
-Polonio, N.C.V.; Rocha, C.L.M.S.C.; Clemente, E. Trans-resveratrol concentrations and antimutagenic potential of juice from the grape cultivars Vênus, BRS Violeta and Isabel. Genetics and Molecular Research. Vol. 13. Num. 1. p. 1152-1159. 2014;
-Prado, A.K.M.; Caetano, M.H.; Benedetti, R.; Benedetti, P.D.C.D. Os efeitos do consumo de vinho na saúde humana. Revista Científica Unilago. Vol. 1. Num. 1. p. 109-128. 2013.
-Ruivo, J.; Francisco, C.; Oliveira, R.; Figueiras, A. The main potentialities of resveratrol for drug delivery systems. Brazilian Journal of Pharmaceutical Sciences. Vol. 51. Num. 3. p. 499-513. 2015.
-Sautter, C.K.; Denardin, S.; Alves, A.O.; Mallmann, C.A.; Penna, N.G.; Hecktheuer, L.H. Determinação de resveratrol em sucos de uva no Brasil. Ciência e Tecnologia de Alimentos. Vol. 25. Num. 3. p. 437-442. 2005.
-Séfora-Sousa, M.; Angelis-Pereira, De. Mecanismos moleculares de ação anti-inflamatória e antioxidante de polifenóis de uvas e vinho tinto na aterosclerose. Rev. bras. plantas med. Vol. 15. Num. 4. p. 617-626. 2013.
-Soares Filho, P.R.; Castro, I.; Stahlschmidt, A. Efeito do vinho tinto associado ao exercício físico no sistema cardiovascular de ratos espontaneamente hipertensos. Arq. Bras. Cardiol. Vol. 96. Num. 4. p. 277-283. 2011.
-Takaoka, M.J. Of the phenolic substances of white hellebore (Veratrum grandiflorum Loes. fil.). J Faculty Sci Hokkaido Imperial University. Vol. 3. p. 1-16. 1940.
-Tosun, I.; Inkaya, A.N. Resveratrol as a health and disease benefit agent. Food Reviews International. Vol. 26. Num. 1. p. 85-101. 2009.
-Tresserra-Rimbau, A.; Medina-Remón, A.; Lamuela-Raventós, R.M.; Bulló, M.; Salas-Salvadó, J.; Corella, D.; Arós, F. Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population. British Journal of Nutrition. Vol. 113. Num. S2. p. S121-S130. 2015.
-Witte, A.V.; Kerti, L.; Margulies, D.S.; Flöel, A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. Journal of Neuroscience. Vol. 34. Num. 23. p. 7862-7870. 2014.
-Yang, L.; Zhang, Y.; Zhu, M.; Zhang, Q.; Wang, X.; Wang, Y.; Liu, F. Resveratrol attenuates myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B. Free Radical Biology and Medicine. Vol. 101. p. 1-9. 2016.
-Zare Javid, A.; Hormoznejad, R.; Zakerkish, M.; Haghighi‐zadeh, M.H.; Dehghan, P.; Ravanbakhsh, M. The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis. Phytotherapy Research. Vol. 31. Num. 1. p. 108-114. 2017.
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