Relationship between obstructive sleep apnea and obesity: a review of endocrine, metabolic and nutritional aspects

  • Iona Zalcman Zimberg Universidade Federal de Sao Paulo
  • Camila Maria de Melo Departamento de Psicobiologia, Universidade Federal de São Paulo
  • Mariana Del Re Departamento de Psicobiologia, Universidade Federal de São Paulo
  • Marcus Vinicius dos Santos Departamento de Biociências, Universidade Federal de São Paulo
  • Cibele Aparecida Crispim Faculdade de Medicina, Universidade Federal de Uberlândia
  • Tássia do Vale Cardoso Lopes Faculdade de Medicina, Universidade Federal de Uberlândia
  • Sérgio Tufik Departamento de Psicobiologia, Universidade Federal de São Paulo
  • Marco Túlio de Mello Departamento de Psicobiologia, Universidade Federal de São Paulo. Departamento de Educação Fí­sica e Esporte, Universidade Federal de Minas Gerais
Keywords: Apnea, Obesity, Metabolism, Weight loss

Abstract

Currently OSAS is recognized as an independent predictor for obesity, and this, in turn, is characterized as the main risk factor for OSAS. This article aims to review the existing literature on the relationship between OSA and obesity, whereas endocrine and metabolic aspects of this relationship and to discuss the role of weight loss in the treatment of this syndrome. Several studies have shown that OSA is directly associated with endocrine disorders such as leptin levels and ghrelin, hormones related to hunger and satiety, and can contribute to increased insulin resistance and cortisol, increasing the risk of chronic diseases such as cardiovascular. Whereas OSAS is an independent risk factor for hypertension and cardiovascular disease, as well as being strongly associated with obesity and insulin resistance, various treatments have been currently proposed, including surgery, oral appliances, CPAP use, as well as changes in lifestyle, which focus on inclusion of exercise and decreased calorie intake, which promotes the reduction of anthropometric measurements and improvement in AHI and respiratory parameters. It is concluded that OSA and obesity trigger endocrine and metabolic disorders, which can negatively affect the health of the individual. Thus, it can be said that the reduction of body mass is clinically important for obese patients with OSAS and should be a measure of important attention in the treatment of this disease.

Author Biography

Iona Zalcman Zimberg, Universidade Federal de Sao Paulo

Departamento de Psicobiologia

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Published
2017-06-18
How to Cite
Zimberg, I. Z., de Melo, C. M., Del Re, M., dos Santos, M. V., Crispim, C. A., Lopes, T. do V. C., Tufik, S., & de Mello, M. T. (2017). Relationship between obstructive sleep apnea and obesity: a review of endocrine, metabolic and nutritional aspects. Brazilian Journal of Obesity, Nutrition and Weight Loss, 11(64), 250-260. Retrieved from https://www.rbone.com.br/index.php/rbone/article/view/527
Issue
Vol. 11 No. 64 (2017)
Section
Scientific Articles - Original

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