Concentration of serum evaluation resistin in obese young adults: a cross study

  • Jaí­ne Bonadeo Departamento de Ciências Biológicas e da Saúde da Universidade do Oeste de Santa Catarina (UNOESC), Laboratório de Bioquí­mica Clí­nica, São Miguel do Oeste, SC, Brasil.
  • Josiele Vogt Departamento de Ciências Biológicas e da Saúde da Universidade do Oeste de Santa Catarina (UNOESC), Laboratório de Bioquí­mica Clí­nica, São Miguel do Oeste, SC, Brasil.
  • Eduardo Ottobelli Chielle Professor do Departamento de Ciências Biológicas e da Saúde da Universidade do Oeste de Santa Catarina (UNOESC), Laboratório de Bioquí­mica Clí­nica, São Miguel do Oeste, SC, Brasil.
Keywords: Resistin, Diabetes, Glucose, Obesity

Abstract

Resistinis a protein produced by adipocytes and macrophages is associated with the development of insulin resistance (IR) and T2DM, and has been demonstrated that this protein is an antagonist of insulin. The objective of this study was to evaluate serum resistin, glucose, HbA1c, insulin in young adults, obese, overweight and normal weight. A cross-sectional study comparing baseline levels of resistin and biochemical parameters were evaluated. 149 young adults were involved in this study, 54 normal weight (18 to 24.9 kg/m2), 27 overweight (25-29.9 kg/m2) and 68 obese (BMI ≥ 30 kg/m2). Obese patients showed resistinlevels, glucose, HbA1c, insulin, and HOMA significantly higher when compared with normal weight patients, and showed significantly reduced insulin sensitivity. Increased production of resistin in obese young adults may be a major factor in the developmentof the inflammatory process and hence RI and DM2 in this population. However, you need larger studies to clarify the exact mechanisms of action of this adipokine in the obese population.

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Published
2015-09-15
How to Cite
Bonadeo, J., Vogt, J., & Ottobelli Chielle, E. (2015). Concentration of serum evaluation resistin in obese young adults: a cross study. Brazilian Journal of Obesity, Nutrition and Weight Loss, 9(54), 265-271. Retrieved from https://www.rbone.com.br/index.php/rbone/article/view/388
Issue
Vol. 9 No. 54 (2015)
Section
Scientific Articles - Original

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