Effects of resveratrol ingestion in mitigating damage from metabolic syndrome: an integrative review
Abstract
Metabolic syndrome represents a highly prevalent pathological condition worldwide, characterized by a combination of chronic metabolic changes that substantially increase health risks for the population. In this scenario, the search for effective treatment and prevention strategies becomes crucial. The aim of this study was to gather evidence on the therapeutic potential of resveratrol in the management of metabolic syndrome through an integrative review. The results of this review indicated that resveratrol shows promising effects in the treatment of metabolic syndrome. The analyzed studies revealed improvements in various aspects of the condition, including glycemic and lipid profiles, reduction in inflammatory and hepatic markers, as well as favorable changes in anthropometric factors. Furthermore, a positive influence on nutrigenetic modulation was observed, suggesting that resveratrol may interact with genes related to metabolic syndrome. Although the results are encouraging, it is important to emphasize the need for additional investigations in various contexts. More comprehensive and randomized studies are required to confirm and deepen our understanding of the benefits of resveratrol in the treatment of metabolic syndrome. However, based on the available evidence so far, resveratrol represents a promising non-pharmacological therapeutic alternative for mitigating the harms associated with this globally concerning health condition.
References
-ABESO. Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica. Mapa da Obesidade. 2019. Disponível em: https://abeso.org.br/obesidade-e-sindrome-metabolica/mapa-da-obesidade/.
-ABESO. Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica. Obesidade e Síndrome Metabólica, 2019. Disponível em: https://abeso.org.br/conceitos/obesidade-e-sindrome-metabolica/
-Akbari, M.; Tamtaji, O.; Lankarani, K.; Tabrizi, R.; Dadgostar, E.; Haghighat, N.; Kolahdooz, F.; Ghaderi, A.; Mansournia, M.; Asemi, Z.;The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. Vol. 19. Num. 25. 2020. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026982/.
-Akbari, M.; Tamtaji, O.; Lankarani, K.; Tabrizi, R.; Dadgostar, E.; Kolahdooz, F.; Jamilian, M.; Mirzaei, H.; Asemi, Z.; The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. High Blood Pressure & Cardiovascular Prevention. Vol. 26. 2019. p. 305–319. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31264084/.
-Amiot, MJ.; Riva, C.; Vinet, A. Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obesity Reviews. Vol. 17. Num. 7. 2016. Disponível em: https://onlinelibrary.wiley.com/doi/full/10.1111/obr.12409.
-Batista-Jorge, G.C.; Barcala-Jorge, A.S.; Silveira, M.F.; Lelis, D.F.; Andrade, J.M.O.; Paula, A.M.B.; Guimarães, A.L.S.; Santos, S.H.S.; Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program. Life Sci. Vol. 256. 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32534040/.
-Leal, J.B.; Carvalho, F.O.; Gonçalves, D.C.; Leal, J.B.; Silva, G.C.L.; Carnevali Júnior, L.C.; Hoefel, A.L. Resveratrol: composição química e seus benefícios à saúde. Revista Brasileira de Obesidade, Nutrição e Emagrecimento. São Paulo. Vol. 11. Num. 67. 2018. p. 620-629. Disponível em: http://www.rbone.com.br/index.php/rbone/article/view/598.
-Ligt, M.; Bergman, M.; Fuentes, R.M.; Essers, H.; Moonen-Kornips, E.; Havekes, B.; Schrauwen-Hinderling, V.B.; Schrauwen, P. No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial. Am J Clin Nutr. Vol. 112. Num. 4. 2020. p.1029-1038. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32492138/.
-Fatima, S.; Khan, D.; Fatima, F.; Aamir, M.; Ijaz, A.; Hafeez, A.; Role of δ-tocotrienol and resveratrol supplementation in the regulation of micro RNAs in patients with metabolic syndrome: A randomized controlled trial. Complement Ther Med, 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37086927/.
-Kjær, T.N.; Ornstrup, M.; Poulsen, M.; Jørgensen, H.; Jessen, N.; Jørgensen, J.; Richelsen, B.; Pedersen, S.; No Beneficial Effects of Resveratrol on the Metabolic Syndrome: A Randomized Placebo-Controlled Clinical Trial J Clin Endocrinol Metab. Vol. 102. Num. 5. 2017. p. 1642-1651. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28182820/.
-Korsholm, A.S.; Kjær, T.N.; Ornstrup, M.; Pedersen, S.; Comprehensive Metabolomic Analysis in Blood, Urine, Fat, and Muscle in Men with Metabolic Syndrome: A Randomized, Placebo-Controlled Clinical Trial on the Effects of Resveratrol after Four Months’ Treatment. Int J Mol Sci. Vol. 18. Num. 3. 2017. p. 554. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372570/.
-Nyambuya, T.M.; Nkambule, B.; Mazibuko-Mbeje, S.E.; Mxinwa, V.; Mokgalaboni, K.; Orlando, P.; Silvestri, S.; Louw, J.; Tiano, L.; Dludla, P.; A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy. Molecules. Vol. 25. Num. 23. 2020. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730696/.
-Oliveira, L.V.A; Santos, B.; Machado, I.; Malta, D.; Velasquez-Melendez, G.; Felisbino-Mendes, M. Prevalência da Síndrome Metabólica e seus componentes na população adulta brasileira. Ciência & Saúde Coletiva. Vol. 25. 2020. p. 4269-4280. Disponível em: https://www.scielo.br/j/csc/a/yjdDz8ccXCGgwj4YhVxKmZc/?lang=pt.
-Pastor, R.F.; Repetto, M.; Lairion, F.; Lazarowski, A.; Merelli, A.; Carabetti, Z.; Pastor, I.; Pastor, E.; Iermoli, L.; Bavasso, C.; Iermoli, R.; Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Nutrients. Vol. 12. Num. 10. 2020. p. 3149. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602615/.
-Salaroli, L.B; Barbosa, G.; Mill, J.; Molina, M.; Prevalência de síndrome metabólica em estudo de base populacional, Vitória, ES - Brasil. Arquivos Brasileiros de Endocrinologia & Metabologia. Vol. 51. Num. 7. 2007.
-Tabrizi, R.; Tamtaji, O.; Lankarani, K.; Mirhosseini, N.; Akbari, M.; Dadgostar, E.; Peymani, P.; Asemi, Z.; The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Food Funct. Vol. 9. Num. 12. 2018. p. 6116-6128. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30426122/.
-Villar, M.M.; González-Ortiz, M.; Martínez-Abundis, E.; Pérez-Rubio, K.; Lizárraga-Valdez, R.; Villar, M. M.; et al. Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion. Metabolic Syndrome and Related Disorders. Vol. 12. Num. 10. 2014. Disponível em: https://www.liebertpub.com/doi/10.1089/met.2014.0082.
-Zeraattalab-Motlagh, S.; Jayedi, A.; Shab-Bidar, S.; The effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trials. Am J Clin Nutr. Vol. 114. Num. 5. 2021. p. 1675-1685. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34320173/.
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