Preparation of a guideline booklet for young people on intuitive eating
Abstract
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder triggered by several factors, including genetic and environmental factors. The main symptoms are digestive and neurological, and nutritional interventions are among the most promising therapies to alleviate clinical symptoms Objective: To map scientific evidence on nutritional interventions for people with Autism Spectrum Disorder (ASD). Materials and Methods: Scoping review performed according to recommendations from The Joanna Briggs Institute, in Medline, Lilacs, Cochrane Library, Embase, SciELO and Web of Science databases. Results: 51 studies published from 2015 to 2022 were selected, presenting high levels of evidence. As for the mapped evidence, the highlights were gluten-free, casein-free and ketogenic diets, food supplements such as folic acid, N-acetylcysteine, probiotics, methyl-B12, trimethylglycerin, B vitamins, magnesium, vitamin D, omega-3 , melatonin and cysteine-rich whey protein isolate, in addition to dietary nutraceuticals such as curcumin, resveratrol, naringerin, sulforaphane and gamma-aminobutyric acid in the form of Oolong tea as the most reported nutritional interventions for nutritional therapy of people with ASD, with indications to reduce stereotyped behaviors and improve communication, cognition and sociability. Conclusion: Food as a therapeutic measure has been shown to be beneficial, making further studies necessary to obtain knowledge of the relationship between nutrition and ASD.
References
-Adams, J. B.; Audhya, T.; Geis, E.; Gehn, E.; Fimbres, V.; Pollard, E. L.; Mitchell, J.; Ingram, J.; Hellmers, R.; Lake, D.; Mateus, J. S.; Li, K.; Naviaux, J. C.; Naviaux, R. K.; Adams, R. L.; Coleman, D. M.; Quig, D. W. Intervenção Nutricional e Dietética Abrangente para Transtorno do Espectro do Autismo - Um Ensaio Randomizado e Controlado de 12 meses. Nutrientes. Vol. 10. p. 369. 2018.
-Alkhalidy, H.; Abushaikha, A.; Alnaser, K.; Obeidat, M. D; Al-Shami, I. Nutritional Status of Pre-school Children and Determinant Factors of Autism: A Case-Control Study. Front Nutr. Vol. 8. Núm. 627011. 2021.
-Bhandari, R.; Paliwal, J. K.; Kuhad, A. Dietary Phytochemicals as Neurotherapeutics for Autism Spectrum Disorder: Plausible Mechanism and Evidence. Adv Neurobiol. Vol. 24. p. 615-646. 2020.
-Burkett, K.; Haggard, M. L.; Van Rafelghem, D.; Restricted Eating in Preschoolers with Autism: Mother Stressors and Solutions. J Autism Dev Disord. 2021.
-Castejon, A. M.; Spaw, J. A.; Rozenfeld, I.; Sheinberg, N.; Kabot, S.; Shaw, A.; Hardigan, P.; Faillace, R.; Packer, E. E. Melhorando a capacidade antioxidante em crianças com autismo: um estudo controlado randomizado e duplo-cego com cisteína-proteína de soro de leite rica. Frente. Psiquiatria. Vol. 12. p.669089. 2021.
-Castillo, M. A.; Urdaneta, K. E.; Semprún-Hernández, N.; Brigida, A. L.; Antonucci, N.; Schultz, S.; Siniscalco, D. Speech-Stimulating Substances in Autism Spectrum Disorders. Behav Sci. Vol. 9. Núm. 6. p. 60. 2019.
-Cekici, H.; Sanlier, N. Current nutritional approaches in managing autism spectrum disorder: A review. Nutr Neurosci. Vol. 22. Núm. 3. p. 145-155. 2019.
-Center For Evidence Based Medicine. Levels of Evidence. 2009. Disponível em: https://www.cebm.net/2009/06/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/. Acesso em: 06/07/2021.
-Croall, I. D.; Hoggard, N.; Hadjivassiliou, M. Gluten and Autism Spectrum Disorder. Nutrients. Vol. 13. Núm. 2. 2021.
-Cupertino, M. C.; Resende, M. B.; Veloso, I. F.; Carvalho, C. A.; Duarte, V. F.; Ramos, G. A. Transtorno do espectro autista: uma revisão sistemática sobre aspectos nutricionais e eixo intestino-cérebro. ABCS Health Sci. Vol. 44. Núm. 2. p. 120-130. 2019.
-Doenyas, C. Dietary interventions for autism spectrum disorder: New perspectives from the gut-brain axis. Physiology & Behavior. Vol. 194. p. 577-582. 2018.
-Doreswamy, S.; Bashir, A.; Guarecuco, J. E.; Lahori, S.; Baig, A.; Narra, L. R.; Patel, P.; heindl, S. E. Effects of Diet, Nutrition, and Exercise in Children With Autism and Autism Spectrum Disorder: A Literature Review. Cureus. Vol. 12. Núm. 12. e12222. 2020.
-El-Rashidy, O.; El-Baz, F.; El-Gendy, Y.; Khalaf, R.; Reda, D.; Saad, K. Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study. Metab Brain Dis. Vol. 32. Núm. 6. p. 1935-1941. 2017.
-Feiyong, J.; Ling, S.; Bing, W.; Honghua, L.; Junyan, F.; Zhida, X.; Khaled, S. Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children: Three cases report. Nutritional Neuroscience. Vol. 22. Núm. 12. p. 863-866. 2018.
-Gogou, M.; Kolios, G. The effect of dietary supplements on clinical aspects of autism spectrum disorder: A systematic review of the literature. Brain Dev. Vol. 39. Núm. 8. p. 656-664. 2017.
-Hamadneh, S. H.; Al-Bayyari, N. M.; Hamadneh, B. Intervenções nutricionais e dietéticas de transtornos do espectro autista: uma breve revisão. Int. J. Pediatr. Vol. 7. Núm. 11. p.10343-348. 2019. DOI: 10.22038/ijp.2019.14031.
-Hannant, P.; Cassidy, S.; Renshaw, D.; Anna Joyce. A double-blind, placebo-controlled, randomised-designed GABA tea study in children diagnosed with autism spectrum conditions: a feasibility study clinical trial registration: ISRCTN 72571312, Nutritional Neuroscience. Disponível em: https://www.tandfonline.com/loi/ynns20. Acesso em: 07/04/2022.
-Hartman, R. E.; Patel, D. Dietary Approaches to the Management of Autism Spectrum Disorders. Adv. Neurobiol. Vol. 24. p. 547-571. 2020.
-Hayashi, M.; Mishima, K.; Fukumizu, M.; Takahashi, H.; Ishikawa, Y.; Hamada, I.; Sugioka, H.; Yotsuya, O.; Yamashita, Y. Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial. J Autism Dev Disord. 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34181143/. Acesso em 10/03/2022.
-Hyman, S. L.; Stewart, P. A.; Schmidt, B.; Cain, U.; Lemcke, N.; Foley, J. T. Ingestão de nutrientes da alimentação em crianças com autismo. Pediatra. Vol. 130. Núm. 2. p. 145-53. 2012.
-Javadfar, Z.; Abdollahzad, H.; Moludi, J.; Rezaeian, S.; Amirian, H.; Foroughi, A. A.; Nachvak, S. M.; Goharmehr, N.; Mostafai, R. Effects of vitamin D supplementation on core symptoms, serum serotonin, and interleukin-6 in children with autism spectrum disorders: A randomized clinical trial. Nutrition. p. 79-80:110986. 2020.
-Joanna Briggs Institute (JBI). Methodology for JBI Scoping Reviews - Joanna Briggs. [Internet]. Australia: JBI. 2015. Disponível em: http://joannabriggs.org/assets/docs/sumari/ Reviewers-Manual_Methodology-for-JBI-Scoping-Reviews_2015_ v2.pdf. Acesso em: 06/07/2021.
-Kałużna-Czaplińska, J.; Jóźwik-Pruska, J.; Chirumbolo, S.; Bjørklund, G. Tryptophan status in autism spectrum disorder and the influence of supplementation on its level. Metab Brain Dis. Vol. 32. p. 1585-1593. 2017.
-Keim, S. A.; Gracious, B.; Boone, K. M.; Klebanoff, M. A.; Rogers, L. K.; Rausch, J.; Coury, D. L.; Sheppard, K. W.; Husk, J.; Rhoda, D. A. ω-3 and ω-6 Fatty Acid Supplementation May Reduce Autism Symptoms Based on Parent Report in Preterm Toddlers. J. Nutr. Vol. 148. p. 227-235. 2018.
-Li, Y. J.; Ou, J. J.; Li, Y-M.; Xiang, D-X. Dietary Supplement for Core Symptoms of Autism Spectrum Disorder: Where Are We Now and Where Should We Go? Frontiers in Psychiatry. Vol. 8. 2017.
-López, G. B.; Valdes, L. C. R.; García, V. E. B.; Gonzalez, I. M. R.; Barragen, M. R. R. Alimentácion em estudiantes com discapacidad. Horizonte sanitário. Vol. 19. Núm. 3. 2020.
-Loyacono, N.; Sanz, M. L.; Gerbi, M. D.; Martínez, L. M. Gastrointestinal, nutritional, endocrine, and microbiota conditions in autism spectrum disorder. Arch Argent Pediatr. Vol. 118. Núm. 3. p. 271-277. 2020.
-Ly, V.; Bottelier, M.; Hoekstra, P. J.; Arias, Vasquez, A.; Buitelaar, J. K.; Rommelse, N. N. Elimination diets' efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry. Vol. 26. Núm. 9. p. 1067-1079. 2017.
-Mazahery, H.; Conlon, C. A.; Beck, K. L.; Mugridge, O.; Kruger, M. C.; Stonehouse, W.; Camargo, C. A. Jr.; Meyer, B. J.; Tsang, B.; Von Hurst, P. R. Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study. Nutrients. Vol. 12. Núm. 3. p.661. 2020.
-Monteiro, M. A. Autism spectrum disorder: a systematic review about nutritional interventions. Revista Paulista de Pediatria. Vol. 38. e2018262. Disponível em: https://doi.org/10.1590/1984-0462/2020/38/2018262.
-Moradi, H.; Sohrabi, M.; Taheri, H.; Khodashenas, E.; Movahedi, A. Comparison of the effects of perceptual-motor exercises, vitamin D supplementation and the combination of these interventions on decreasing stereotypical behavior in children with autism disorder, International Journal of Developmental Disabilities. 2018.
-Narzisi, A.; Mais, G.; Grossi, E. Nutrition and Autism Spectrum Disorder: Between False Myths and Real Research-Based Opportunities. Nutrients. Vol. 13. Núm. 6. p.2068. 2021.
-Pennesi, C. M.; Klein, L. C. Eficácia do sem glúten, caseína dieta gratuita para crianças diagnosticadas com transtorno do espectro autista: com base no relato dos pais. Nutr Neurosci. Vol. 15. Núm. 2. p. 85-91. 2012.
-Peters, M. D. J.; Godfrey, C.; Mcinerney, P.; Munn, Z.; Tricco, A. C.; Khalil, H. Chapter 11: Scoping Reviews (2020 version). In: Aromataris E, Munn Z (Editors). Joanna Briggs Institute Reviewer´s Manual, JBI. 2020. Disponível em: https://reviewersmanual.joannabriggs.org/. Acesso em: 06/07/2021.
-Piwowarczyk, A.; Horvath, A.; Łukasik, J.; Pisula, E.; Szajewska, H. Gluten- and casein-free diet and autism spectrum disorders in children: a systematic review. Eur J Nutr. Vol. 57. Núm. 2. p. 433-440. 2018.
-Reissmann, A.; Hauser, J.; Makulska-Gertruda, E.; Tomsa, L.; Lange, K. W. Dietas sem glúten e sem caseína no tratamento do autismo. Funct Foods Health Dis. Vol. 4. Núm. 8. p. 349-61. 2014.
-Renard, E.; Leheup, B.; Guéant-Rodriguez, R. M.; Oussalah, A.; Quadros, E. V.; Guéant, J. L. Folinic acid improves the score of Autism in the EFFET placebo-controlled randomized trial. Biochimie. Vol. 173. p. 57-61. 2020.
-Robea, M. A.; Luca, A. C.; Ciobica, A. Relationship between Vitamin Deficiencies and Co-Occurring Symptoms in Autism Spectrum Disorder. Medicina. Vol. 56. Núm. 5. p. 245. 2020.
-Silva, D. V.; Santos, P. N. M.; Silva, D. A. V. Excess weight and gastrointestinal symptoms in a group of autistic children. Revista Paulista de Pediatria. Vol. 38. e2019080. 2020. Disponível em: https://doi.org/10.1590/1984-0462/2020/38/2019080.
-Sumathi, T.; Manivasagam, T.; Thenmozhi, A. J. The Role of Gluten in Autism. Adv Neurobiol. Vol. 24. p. 469-479. 2020.
-Sun, C.; Zou, M.; Zhao, D.; Xia, W.; Wu, L. Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial. Nutrients. Vol. 8. Núm. 6. p. 337. 2016.
-Theije, C. G.; Wu, J.; Silva, S. L.; Kamphuis, P. J.; Garssen, J.; Korte, S. M. Caminhos subjacentes à conexão intestino-cérebro em transtornos do espectro do autismo como alvos futuros para o gerenciamento de doenças. Eur J Pharmacol. Vol. 668. Núm. 1. p. 70-80. 2011.
-Trudeau, M. S.; Madden, R. F.; Parnell, J. A.; Gibbard, W. B.; Shearer, J. Dietary and Supplement-Based Complementary and Alternative Medicine Use in Pediatric Autism Spectrum Disorder. Nutrients. Vol. 11. Núm. 8. p. 1783. 2019.
-Tsujiguchi, H.; Miyagi, S.; Nguyen, T. T. T.; Hara, A.; Ono, Y.; Kambayashi, Y.; Shimizu, Y.; Nakamura, H.; Suzuki, K.; Suzuki, F.; Nakamura, H. Relationship between Autistic Traits and Nutrient Intake among Japanese Children and Adolescents. Nutrients. Vol. 12. Núm. 8. p.2258. 2020.
-Vartanian, C. Overview of Nutritional Therapy for Autism Spectrum Disorder. Adv Neurobiol. Vol. 24. p. 527-534. 2020.
-Westmark, C. J. Parental Reports on Early Autism Behaviors in Their Children with Fragile X Syndrome as a Function of Infant Feeding. Nutrients. Vol. 13. Núm. 8. p. 2888. 2021.
-Westmark, C. J. Consumption of Breast Milk Is Associated with Decreased Prevalence of Autism in Fragile X Syndrome. Nutrients. Vol.13. Núm. 6. p. 1785. 2021.
-Zhu, J.; Guo, M.; Yang, T.; Lai, X.; Tang, T.; Chen, J.; Li, L.; Li, T. Nutritional Status and Symptoms in Preschool Children With Autism Spectrum Disorder: A Two-Center Comparative Study in Chongqing and Hainan Province, China. Front. Pediatr. Vol. 8. p. 469. 2020.
Copyright (c) 2023 Ana Kelly Morais dos Santos, Rogênia Rocha Nascimento, Evanira Rodrigues Maia, José Hiago Feitosa de Matos

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish in this journal agree to the following terms:
- Authors retain the copyright and grant the journal the right of first publication, with work simultaneously licensed under the Creative Commons Attribution License BY-NC which allows the sharing of the work with acknowledgment of the authorship of the work and initial publication in this journal.
- Authors are authorized to enter into additional contracts separately for non-exclusive distribution of the version of the work published in this journal (eg, publishing in institutional repository or book chapter), with acknowledgment of authorship and initial publication in this journal.
- Authors are allowed and encouraged to post and distribute their work online (eg, in institutional repositories or on their personal page) at any point before or during the editorial process, as this can bring about productive change as well as increase impact and impact. citation of published work (See The Effect of Free Access).