The relationship of the gut microbiota with obesity and insulin resistance

  • Danielle Giovanini Lage Lage Programa de Pós-Graduação Lato-Sensu do IPGS -Nutrição Clínica e Estética
  • Gleisson Alisson Pereira de Brito Universidade Gama Filho (UGF)

Abstract

Introduction: Obesity is a public health problem, being observed rapidly increasing prevalence. This diseases is associated with several comorbiditys such as metabolic syndrome, diabetes and cardiovascular disease. Additionally, recent studies have hypostatized that obesity can be related to alterations in the gut microbiome. On this sense, two major bacterial phyla: Firmicutes and Bacteroidetes found in the small and large intestine, have being studied. In fact, evidences have indicated thatimbalance in the proportions of these two populations may lead not only obesity butalso the insulin resistance. Objective: To analyze the interference Firmicutes and Bacteroidetes bacteria found in the gut with the weight gain and insulin resistance. Materials and methods: A literature review of articles from the databases and specific sites in the area of health, published since 2002. Literature review: We evaluated the relationship between intestinal microbiota with obesity and insulin resistance in rats and humans. Conclusion: The gut flora of the obese patient is different from the thin, both inhumans and mice and that this is related to obesity and insulin resistance. There are changes in the phyla Firmicutes and Bacteroidetes bacteria compared to obese and thin.

References

-Backhed, F.; Ding, H.; Wang, T.; Hooper, L. V.; Koh, G. Y.; Nagy, A.; Semenkovich, C. F.; Gordon, J. I. The gut microbiota as an environmental factor that regulates fat storage. PNAS. USA. Vol. 101. Num. 44. 2004. p. 15718-15723.

-Carvalheira, J.B.C.; Zecchin, H.G.; Saad, M.J.A. Vias de sinalização da insulina. Arq. Bras. Endocrinol. Metab. São Paulo. Vol. 46. Num. 4. 2002. p. 420.

-Correa, C. A. G.; Correa, C. H. G. Globesidad y su posible componente infeccioso. Colombia. Vol. 8. 2009. p. 132-142.

-Diamant, M.; Blaak, E. E.; Vos, W. M. Do nutrient gut microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?. Internacional Assoc for the study of obesity.Europe. Vol. 797. 2010. p. 1-10.

-Duncan, S. H.; Lobley, G. E.; Holtrop, G. Human colonic microbiota associated with diet, obesity and weight loss. Int. J. Obesity. USA. Vol. 32. 2008. p. 1720-1724.

-Esteve, E.; Ricart, W.; Real, J. M. F. Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve with insulin resistance?. Nutr metab Care. USA. Vol.14. 2011. p. 483-490.

-Ley, R. E.; Backhed, F.; Turnbaugh, P.; Lozupone, C. A.; Knight, R. D.; Gordon, J. I. Obesity alters gut microbial ecology. Proc. Natl Acad Sci. USA. Vol. 102. Num. 31. 2005. p. 11070-11075.

-Musso, G.; Gambino, R.; Cassader, M. Obesity, diabetes, and gut microbiota. Diabetes Care. USA. Vol. 33. Num. 10. 2010. p. 2277-2284.

-Pistelli, G. C.; Costa, C. E. M. Bactérias intestinais e obesidade. Revista Saúde e Pesquisa. São Paulo. Vol. 3. Num. 1. 2010. p. 115-116.

-Rodrigues, A. Microbiota intestinal e sua possível relação com a obesidade. Abeso. São Paulo. Vol. 53. 2011. p. 5.

-Sanz, Y.; Santacruz, A.; Dalmau, J. Influencia de la microbiota intestinal em la obesidad y las alteraciones Del metabolismo. Revista Acta Pediatrica Esp. Espanha. Vol. 67. Num. 9. 2009. p. 437-442.

-Tilg, H.; Moschen, A. R.; Kaser, A. Obesity and the microbiota. Gastroenteroloy. Austria. Vol. 136. 2009. p. 1476-1483.

-Turnbaugh, P. J.; Ley, R. E.; Mahowald, M. A.; Magrini, V.; Mardis, E. R.; Gordon, J. I. Na obesity-associated gut microbiome with increased capacity for energy harvest. Nature. USA. Vol. 444. 2006. p. 21-28.

Published
2012-05-03
How to Cite
Lage, D. G. L., & Brito, G. A. P. de. (2012). The relationship of the gut microbiota with obesity and insulin resistance. Brazilian Journal of Obesity, Nutrition and Weight Loss, 6(31). Retrieved from https://www.rbone.com.br/index.php/rbone/article/view/189
Issue
Vol. 6 No. 31 (2012)
Section
Scientific Articles - Original

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