Overfeeding in lactation program metabolic changes at weaning in male wistar rats

  • Delmo Luiz Ribeiro Neto Centro de Ciências da Saúde, Unicesumar, Maringá-PR, Brasil.
  • Rafael Andrade Cintra Mercadante Leite do Canto Centro de Ciências da Saúde, Unicesumar, Maringá-PR, Brasil.
  • Isabela Peixoto Martins Centro de Ciências Biológicas, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá-PR, Brasil.
  • Paulo Cezar de Freitas Mathias Centro de Ciências Biológicas, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá-PR, Brasil.
  • Audrei Pavanello Centro de Ciências da Saúde, Unicesumar, Maringá-PR, Brasil; Centro de Ciências Biológicas, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá-PR, Brasil.
Keywords: Obesity, Lactation, Overfeeding

Abstract

The importance of nutrition during childhood is recognized in the literature. It is known that nutritional insults in critical periods of development can program the metabolism for consequences that last until adulthood. The aim of the work was to evaluate the effects caused by overfeeding during lactation on the infant's metabolic parameters. For that, male rats were evaluated in the litter reduction model to simulate overfeeding in the reduced litters. The rats were kept in a controlled environment and weighed every two days, with euthanasia at 21 days, at weaning. The nasoanal length of the pups was measured, the main fat reserves were collected, as well as the liver, for weighing and evaluation of the biometric parameters. In addition, blood was collected from the puppies and the mothers' milk for biochemical analysis. The animals submitted to overfeeding showed an increase in total weight, as well as a major increase in their main fat reserves. In addition to the increase in weight, they showed metabolic dysfunction, such as increased levels of total cholesterol and triglycerides. The biochemical composition of the milk showed no difference between the groups analyzed. It is concluded that rats overfed during lactation present metabolic and biometric disorders at 21 days of life. The findings reinforce the importance of healthy eating at the beginning of life to avoid metabolic disorders at this stage and in adult life.

References

-Apovian, C.M. Obesity: definition, comorbidities, causes, and burden. Am J Manag Care. Vol. 22. Num. 7. 2016. p. 176-185.

-Blüher, M. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology. Vol. 15. Num. 1. 2019. p. 288-298.

-Desai, M.; Jellyman, J.K.; Ross, M.G. Epigenomics, gestational programming and risk of metabolic syndrome. International Journal of Obesity. Vol. 39. Num. 4. 2015. p. 633-641.

-Fernández, N.; Monge, L.; Carreño-Tarragona, G.; Figueras, J.C.; Amor, S.; García-Villalón, A. L. Long-Term Effects of Early Overnutrition in the Heart of Male Adult Rats: Role of the Renin-Angiotensin System. Plos one. Vol. 8. Num. 6. 2013. p. 1-11.

-Habbout, A.; Delemasure, S.; Goirand, F.; Guilland, J.C.; Chabod, F.; Sediki, M.; Rochette, L.; Vergely, C. Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood. Biochimie. Vol. 94. Num. 1. 2012. p. 117-124.

-Habbout, A.; Li, N.; Rochette, L.; Vergely, C. Postnatal overfeeding in rodents by litter size reduction induces major short-and long-term pathophysiological consequences. The Journal of Nutrition. Vol. 143. Num. 5. 2013. p. 553-562.

-Junior, M.D.F.; Cavalcante, K.V.N.; Ferreira, L.A.; Lopes, P.R.; Pontes, C.N.R.; Bessa, A.S.M.; Neves, Â.R.; Francisco, F.A.; Pedrino, G.R.; Xavier, C.H.; Mathias, P.C.F.; Castro, C.H.; Gomes, R.M. Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats. Life Science. 2019. p. 173-184.

-Marousez, L.; Lesage, J.; Eberlé, D. Epigenetics: Linking Early Postnatal Nutrition to Obesity Programming? Nutrients. Vol. 11. Num. 12. 2019. p. 1-23.

-Plagemann, A. A matter of insulin: developmental programming of body weight regulation. The Journal of Maternal-Fetal and Neonatal Medicine. Vol. 21. Num. 3. 2008. p. 143-148.

-Plagemann, A. Perinatal Nutrition and Hormone-Dependent Programming of Food Intake. Hormone Research. Vol. 65. Num. 3. 2006. p. 83-89.

-Pomar, C.A.; Castro, H.; Picó, C.; Palou, A.; Sánchez, J. Maternal Overfeeding during Lactation Impairs the Metabolic Response to Fed/Fasting Changing Conditions in the Postweaning Offspring. Molecular Nutrition and Food Research. Vol. 63. Num. 20. 2019. p. 1-29.

-Reynolds, C.M.; Gray, C.; Li, M.; Segovia, S.A.; Vickers, M.H. Early Life Nutrition and Energy Balance Disorders in Offspring in Later Life. Nutrients. Vol. 7. Num. 9. 2015. p. 8090-8111.

-Ribeiro, T.A.; Tófolo, L.P.; Martins, I.P.; Pavanello, A.; Oliveira, J.C.; Prates, K.V.; Miranda, R.A.; Franco, C.C.S.; Gomes, R.M.; Francisco, F.A.; Alves, V.S.; Almeida, D.L.; Moreira, V.M.; Palma-Rigo, K.; Vieira, E.; Fabricio, G.S.; Rodrigues, M.R.S.; Rinaldi, W.; Malta, A.; Mathias, P.C.F. Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition. Scientific Reports. Vol. 7. Num. 7634. 2017. p. 1- 11.

-Simões, F.C.; Marques, R.G.; Diestel, C.F.; Caetano, C.E.R.; Dinis, A.P.G.; Horst, N.L.; Neto, J.F.N.; Portela, M.C. Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant. Acta Cir. Bras. Vol. 22. Num. 1. 2007. p. 46-51.

-Sociedade Brasileira de Cardiologia. Atualização da diretriz brasileira de dislipidemias e prevenção da aterosclerose. Arquivos Brasileiros de Cardiologia. Vol. 109. Num. 1. Rio de Janeiro. 2017.

-Van Dijk, S.J.; Molloy, P.L.; Varinli, H.; Morrison, J.L.; Muhlhausler, B.S.; Members of EpiSCOPE. Epigenetics and human obesity. International Journal of Obesity. Vol. 39. Num. 1. 2015. p. 85-97.

-Vickers, M.H. Early life nutrition, epigenetics and programming of later life disease. Nutrients. Vol. 6. Num. 6. 2014. p. 2165-2178.

Published
2022-08-06
How to Cite
Ribeiro Neto, D. L., Canto, R. A. C. M. L. do, Martins, I. P., Mathias, P. C. de F., & Pavanello, A. (2022). Overfeeding in lactation program metabolic changes at weaning in male wistar rats. Brazilian Journal of Obesity, Nutrition and Weight Loss, 15(98), 1305-1314. Retrieved from https://www.rbone.com.br/index.php/rbone/article/view/1595
Issue
Vol. 15 No. 98 (2021): Suplementar 1
Section
Scientific Articles - Original

Copyright (c) 2022 Delmo Luiz Ribeiro Neto, Rafael Andrade Cintra Mercadante Leite do Canto, Isabela Peixoto Martins, Paulo Cezar de Freitas Mathias, Audrei Pavanello

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