Frequency of micronucleus and factors associated with the risk for chronic non-communicable diseases
Abstract
The adoption of a diet with a high amount of ultra-processed foods has contributed to the increase in Chronic Non-Communicable Diseases (CNCD) and the Body Mass Index (BMI) of the population. An alternative to monitor the frequency of DNA damage from environmental factors is the determination of micronuclei (MN). The association between the high frequency of MN and several pathologies has been evaluated and detected in epithelial cells of the oral mucosa. This study aimed to evaluate the frequency of micronuclei in the oral mucosa and the factors associated with CNCDs in individuals from the city of Caxias do Sul-RS. The study included individuals of both sexes, aged over 18 years. The collection of epithelial samples of the oral mucosa was performed with the aid of a swab for further analysis of MN. At the end of the research, 111 samples were collected, where it was observed that the mean MN was 3.23 ± 2.18 cells, of which 66 individuals (59.5%) were classified as normal (from 1 to 3 cells / 1000), and in 45 individuals (40.5%) the cells classified them as a risk for the development of NCDs (> 3 cells / 1000). Such findings indicate that eating habits, lifestyle and other factors directly interfere with the manifestation of MN in the oral mucosa of the population.
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