Therapy approach associate with carnitine supplementation and physical exercise in the HIV lipodystrophic syndrome

Abstract

The introduction of Highly Active Antiretroviral Therapy (HAART) has reduced morbidity and mortality in patients infected with Acquired Immunodeficiency Syndrome. However, prolonged treatment with combination regimens can be difficult to sustain because of problems with adherence and side effects. Treatment with antiretroviral agents – protease inhibitors in particular – has uncovered syndrome of abnormal fat redistribution, impaired glucose metabolism, insulin resistance and dyslipidemia, collectively termed lipodystrophy syndrome (SLHIV).The lack of a clear and easy definition reflects the clinical heterogeneity. Therapeutic and prevention strategies have so far been of only limited clinical success. Thus, general recommendations include dietary changes and life style modifications, altering antiretroviral drug therapy, and finally, the use of metabolically active supplement. Therefore, the purpose of this review emphasizes the clinical features and data from previous studies about the SLHIV was to describe the use of Carnitine supplementation and exercise training in subjective with special needs and susceptible like for HIV infected patients, so as specialists, cardiologists, endocrinologists and personal training be allowed to a real knowledge about this therapy effect for the desease control.