Association between vitamin a deficiency and anthropometric markers in individuals with class III obesity

  • Luana Azevedo Aquino Programa de Pós Graduação Lato Sensu em Obesidade e Emagrecimento- UGF. Mestranda em Nutrição Humana. Professor Substituto do Departamento de Nutrição Social e Aplicada. Pesquisadora do Núcleo de Pesquisa em Micronutrientes (INJC/UFRJ)
  • Silvia Elaine Pereira Clí­nica Cirúrgica Carlos Saboya. Doutoranda em Clí­nica Médica. Pesquisadora do Núcleo de Pesquisa em Micronutrientes (INJC/UFRJ)
  • Carlos José Saboya Sobrinho Clí­nica Cirúrgica Carlos Saboya. SBCBM. Pesquisador do Núcleo de Pesquisa em Micronutrientes (INJC/UFRJ)
  • Andréa Ramalho Doutora em Ciências (ENSP/FIOCRUZ). Professor Titular do Departamento de Nutrição Social e Aplicada, Coordenadora do Núcleo de Pesquisa em Micronutrientes (INJC/UFRJ)
Keywords: Obesity, Vitamin A, Retinol, Vitamin A deficiency

Abstract

The objective of the present study was to evaluate the nutritional status of VA according to the biochemical marker (serum levels of retinol) and its association with anthropometric markers in individuals with class III obesity. Material and Methods: Data collection was conducted in the preoperatory of Gastric Bypass surgery in a private clinic in Rio de Janeiro. Serum levels of retinol were quantified by HPLC- UV method, with VAD cutoff of <1.05 μmol/L (WHO, 1996). The anthropometric evaluation included weight and height for calculation of the body mass index (BMI), waist circumference (WC), hip circumference (HC) and waist-hip circumference (WHC) according to the cutoffs recommended in literature. Results: One hundred and three patients of both genders with BMI >40 kg/m2 and with mean age of 36.4±11.7 years were evaluated. The prevalence of inadequate serum retinol (VAD) was 13.6%. There was negative and significant correlation between the serum levels of retinol and BMI. The correlation between serum retinol, WC and HC was negative and non significant but it presents clinical importance. Conclusion: The findings of the present study suggest that BMI, WC and HC, methods which are of easy application in clinical practice, of low cost and less invasive, may corroborate the diagnosis of VAD in individuals with class III obesity.

References

- Aeberli, I.; Biebinger, R.; Lehmann, R.; l’Allemand, D.; Spinas, G.A.; Zimmermann, M.B. Serum Retinol-Binding Protein 4 Concentration and Its Ratio to Serum Retinol Are Associated with Obesity and Metabolic Syndrome Components in Children. J Clin Endocrinol Metab, 2007, 92(11):4359–4365.

- Andersen, L.F.; Solvoll, K.; Johansson, L.R.K.; Salminen, I.; Antti, A.; Drevon, C.A. Evaluation of a Food Frequency Questionnaire with Weighed Records, Fatty Acids, and Alpha-Tocopherol in Adipose Tissue and Serum. Am J Epid. 150(1):75-87, July 1, 1999.

- Batista Filho, M.; Rissin, A. A transição nutricional no Brasil: tendências regionais e temporais. Cad Saúde Pública 2003; 19 Suppl 1:S181-91.

- Bonet, M.L.; Ribot, J.; e colaboradores. Vitamin A and the regulation of fat reserves. Cel and Mol Lif Scien. v. 60, p. 1311-21. 2003.

- Buijsse, B.; Feskens, E.J.; Schlettwein-Gsell, D.; e colaboradores. Plasma carotene and alfa-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the Survey in Europe on Nutrition and the Elderly, a Concerted Action (SENECA). Am J Clin Nutr 2005;82:879–86.

- Cynthia, L.; Ogden Margaret, D.; Carroll Lester, R.; Curtin Margaret, A.; McDowell Carolyn, J.; Tabak Katherine, M. Flegal. Prevalence of Overweight and Obesity in the United States, 1999-2004 JAMA, April 5, 2006; 295: 1549 - 1555.

- Czernicho, S.; Hercberg, S. Interventional studies concerning the role of antioxidant vitamins in cardiovascular diseases: a review. J Nutr. v. 5, p. 188- 195. 2001.

- Deprés, J.P. Health consequences of visceral obesity. Ann Med. 8:534-41, 2001.

- Empana, J.P.; Ducimetiere, P.; Charles, M.A.; Jouven, X. Sagittal abdominal diameter and risk of sudden death in asymptomatic middle-aged men: the Paris Prospective Study I. Circulation. 2004;110:2781–2785.

- Felipe, F.; Bonet, M.L.; Ribot, J.; Palou, A. Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatment. Int J Obes and Relat Metab Disord. v. 27, p. 60-69. 2003.

- Ford, E.S.; Giles, W.H.; Dietz, W.H. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. v. 287, p. 356-9. 2002.

- Ford, E.S.; Giles, W.H.; Mokdad, A.H. Increasing prevalence of the metabolic syndrome among US adults. Diabetes Care. 2004; 10:2444-9

- Freedman, D.S.; Khan, L.K.; Serdula, M.K.; e colaboradores. Trends and correlates of class 3 obesity in the United States from 1990 through 2000. JAMA. v. 188, p. 1758-61. 2002.

- IBGE (Fundação Instituto Brasileiro de Geografia e Estatística). Pesquisa de orçamentos familiares 2002-2003: Análise da disponibilidade domiciliar de alimentos e do estado nutricional no Brasil. Rio de Janeiro: Ministério do Planejamento e Orçamento/IBGE. 2004.

- IOM (Institute of Medicine). Vitamin A. In: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. p. 82-161. Washington: National Academy Press. 2001.

- IVACG (International Vitamin A Consultative Group). IVACG Statement. Maternal night blindness: A new indicator of vitamin A deficiency. USA: IVACG. 2002.

- Jeyakumar, S.M.; Vajerswaria, A.; Giridharan, N.V. Chronic dietary vitamin A supplementation regulates obesity: in obese mutant rat model of WNIN/Ob strain. Obesity research. J Mol Endocrinol. v. 35, p. 391-398. 2006.

- Jeyakumar, S.M.; Vajerswaria, A.; Giridharan, N.V. Impact of vitamin A on highdensity lipoprotein-cholesterol and scavenger receptor class BI in the obese rat. Obesity. V. 15, p. 322-9. 2007.

- Jia, W.; Wu, H.; Bao, Y.; Wang, C.; Lu, J.; Zhu, J.; Xiang, K. Association of Serum Retinol-Binding Protein 4 and Visceral Adiposity in Chinese Subjects with and without Type 2 Diabetes. J Clin Endocrinol Metab. 2007; 92(8):3224–3229.

- Kumar, M.V.; Sunvold, G.D.; Scarpace, P.J. Dietary vitamin A supplementation in rats: suppression of leptin and inducion of UCP1 mRMA. Journal of lipid research. v. 40, p. 824-829. 1999.

- Lohman, T.G.; Roche, A.F.; Martorell, R. Anthropometric Standardization Reference Manual. Champaign, III. Human Kinetics Publishers, 1998.

- Malta, D.C.; Cezário, A.C.; Moura, L.; Morais Neto, O.L.; Silva Jr, J.B. Construção da vigilância e prevenção das doenças crônicas não transmissíveis no contexto do sistema único de saúde. Epidemiol Serv Saúde 2006; 15 (3): 47-64.

- Matsuoka, H. Endothelial dysfunction associated with oxidative stress in human. Diab Res Clin Pract. v. 54, p. S65-S72. 2001.

- Mercader, J.; Madsen, L.; Felipe, F.; Palou, A.; Kristiansen, K.; Bonet, M.L. All-Trans Retinoic Acid Increases Oxidative Metabolism in Mature Adipocytes. Cell Physiol Biochem. 2007;20:1061-1072.

- Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Análise de Situação em Saúde. Saúde Brasil 2006: uma análise da situação de saúde no Brasil. Brasília: Ministério da Saúde; 2006.

- Monteiro, C.A.; Conde, W.I. A tendência secular da obesidade segundo estratos sociais: nordeste e sudeste do Brasil, 1975-1989-1997. Arq Bras Endocrinol Metab. v. 3, n. 43, p. 186-94. 1999.

- Mosca, L.; Rubenfire, M.; Mandel, C.; e colaboradores. Antioxidant Nutrient Supplementation Reduces the Susceptibility of Low Density Lipoprotein to Oxidation in Patients With Coronary Artery Disease. J Am Coll of Cardiol. v. 30, n. 2, p. 392-9. 1997.

- Puigserver, P.; Vasquez, F.; Bonet, M.L.; e colaboradores. In vivo and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. Biochemical journal. v. 317, p. 827-833. 1996.

- Ramalho, RA.; Flores, H.; Accioly, E.; e colaboradores. Deficiência de vitamina A no Brasil. Soc Iber Nutr. 2005.

- Sarni, RS.; Kochi, C.; e colaboradores. Impact of vitamin A megadose supplementation on the anthropometry of children and adolescents with non-hormonal statural deficit: a double-blind and randomized clinical study. Int J Vitam Nutr Res. v. 73, p. 303-11. 2003.

- Shetty, P.; Shimidhuber, J. Introductory lecture the epidemiology and determinants of obesity in developed and developing countries. Int. J. Vitam. Nutr. Res. v. 4, n. 76, p. 157-162. 2006.

- Silva, L.S.V.L.; Veiga, G.V.V.; Ramalho, R.A. Association of serum concentrations of retinol and carotenoids with overweight in children and adolescents. Nutrition. v. 23, p. 392-397. 2007.

- Singh, R.B.; Niaz, M.A.; Bishnoi, I.; e colaboradores. Diet, antioxidant vitamins, oxidative stress and risk of coronary artery disease: the peerzada prospective study. Int J Cardiol. v. XLIX, n. 5, p. 453-467. 1994.

- Sorensen, T.I. The changing lifestyle in the world: body weitght and what else? Diabetes Care. v. 2, n. 23, p. 1-4. 2000.

- Torrance, G.M.; Hooper, M.D.; Reeder, B.A. Trends in overweight and obesity among adults in Canada (1970-1992): evidence from national surveys using measured height and weight. Int J Obesity. 2002; 26: 797-804.

- Virtanen, S.M.; van't Veer, P.; Kok, F.; Kardinaal, A.; Aro, A. Predictors of Adipose Tissue Carotenoid and Retinol Levels in Nine Countries. Am J Epidemiol Vol. 144, No. 10, 1996

- Wallström, P.; Wirfält, E.; Lahmann, P.H.; Gullberg, B.; Berglund, L.J. Serum concentrations of ß-carotene and -tocopherol are associated with diet, smoking, and general and central adiposity. Am J Clin Nutr. Vol. 73, No. 4, 777-785, 2001.

- WHO (World Health Organization). Global Prevalence of Vitamin A. Indicators for assessing Vitamin A deficiency and their application in monitoring and evaluating intervention programmers. Micronutrient Series, WHO/NUT. 10. Geneva, Switzerland.1996.

- WHO (World Health Organization). Obesity: preventing and managing the global epidemic. Report of WHO consultation on obesity. World health organization, Geneva. 1998.

Published
2012-01-28
How to Cite
Aquino, L. A., Pereira, S. E., Sobrinho, C. J. S., & Ramalho, A. (2012). Association between vitamin a deficiency and anthropometric markers in individuals with class III obesity. Brazilian Journal of Obesity, Nutrition and Weight Loss, 2(11). Retrieved from https://www.rbone.com.br/index.php/rbone/article/view/102
Section
Scientific Articles - Original