Association of the tumor necrosis factor alpha (TNF-α) with the obesity
Abstract
This study had as objective to evaluate the association between the Tumor Necrosis Factor Alpha (TNF-α) and the obesity, allowding to define more clearly the role of the adipocytes in health and obesity, and how the TNF-α acts signaling the molecules on this process, through a bibliographical review. The data were collected on internet sites and scientific magazines papers, approaching articles released since 1995. Several studies suggest that obesity is characterized by the increase of adipose tissue, now considered an active endocrine organ, that secretes a variety of substances metabolical like hormones, clotting proteins and many proinflammatory factors, including the TNF-α. This study intends to show the importance of the TNF-αas a multifunctional cytokine with central role of defense, on which exercises several biological activities, as well as on the development and phenotypical expression of obesity, because it acts straight on the adipocytes, regulating the fat accumulation and interfering directly in the metabolism of the lipids, inhibiting the lipogenesis and increasing the lipolysis on the adipocytes.
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